The LHC experiments have performed analyses on the existing data sets, studying the case of one vector-like fermion or multiplet coupling to the standard model generations. The presence of more than one extra multiplet and of a more complete mixing structure is a common situation in many extensions of the standard model. The interplay of these multiplets concerning precision electroweak bounds, flavour and collider phenomenology is a question which is important in view of establishing bounds or for the discovery of physics beyond the standard model. I will establish the general mixing structure with all the standard model generations and discuss specific interesting cases used in extensions of the standard model.