Orateur
Dr
Olivier RIVOIRE
(Laboratoire Interdisciplinaire de Physique Université Grenoble I et CNRS)
Description
I will present work aimed at deciphering the relation between the sequence and function of proteins based on the principle of co-evolution. By analyzing statistically large numbers of related sequences, we can infer from this principle the patterns of functional couplings between amino acids in a protein. This analysis reveals a decomposition of proteins into evolutionary units that differs from the usual decomposition of proteins into a hierarchy of structural units. I will describe this new decomposition, explain how it is obtained, and show some of the experimental evidence.
